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Senescent Cells: Key Strategies for Managing Aging Senescent Cells: Key Strategies for Managing Aging and Disease | Health Senescent cells are non-dividing cells that accumulate with age and contribute to aging and diseases. They secrete the senescence-associated secretory phenotype (SASP), including pro-inflammatory cytokines, chemokines, and proteases. This secretion damages neighboring cells, impairs tissue function, and promotes chronic inflammation, which is associated with cardiovascular disease, diabetes, osteoporosis, and cancer. Health Implications: - Aging: Senescent cells disrupt tissue repair and regeneration and create an inflammatory environment leading to scarring or fibrosis. - Chronic Diseases: The SASP worsens conditions such as arthritis, lung disease, and neurodegeneration. In obesity, an increase in senescent cells can lead to insulin resistance, worsening diabetes. - Cancer: Although senescence initially prevents damaged cells from proliferating, the SASP can eventually promote tumor development by altering the tissue microenvironment. Management Strategies: - Senolytics: Drugs that target and eliminate senescent cells include: - Dasatinib and Quercetin: Dasatinib targets senescent fat progenitors, while quercetin addresses endothelial cells and other types. - Fisetin: A flavonoid that has been shown to reduce senescent cells and extend lifespan in animal models. - Exercise: High-intensity interval training (HIIT) can decrease senescent cell levels in skeletal muscle and lower systemic inflammation. - Immune Activation: Invariant Natural Killer T (iNKT) cells, when activated with lipid antigens, can clear senescent cells, suggesting potential for immunotherapy. Lifestyle Adjustments: - Caloric Restriction: Lowers senescent cells by limiting energy and boosting autophagy. - Antioxidants and Anti-inflammatory Compounds: Reduce oxidative stress and senescence with compounds like resveratrol and curcumin. - Genetic Approaches: Enhances removal or programmed death of senescent cells through genetic engineering. - Future Therapies: Develops targeted treatments to rejuvenate or remove senescent cells while sparing healthy tissue. — Doolly Noted #antiaging #aging
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12 Sep

Fragrances and Hormone Disruption: What You Need to Know | Health

Fragrances, particularly those found in personal care products and household items, contain a myriad of chemicals, many of which can disrupt hormonal balance. Synthetic fragrances often include phthalates,…

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